Aqualon

Klucel® hydroxyproplycellulose (HPC) provides premier a unique combination of thermoplasticity with organic solvent preparation using many different formulation techniques

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Aqualon® EC is an non-ionic ethyl ether of cellulose, soluble in a wide range of organic solvents. When water-soluble binders cannot be used because of processing problems or water sensitivity of the active ingredient, ethylcellulose is often the polymer of choice. Ethylcellulose can be used to coat one or more active ingredients of a tablet to prevent them from reacting with other materials or with one another. It can prevent discoloration of easily oxidizable substances such as ascorbic acid. Granulations of ascorbic acid made with ethylcellulose are easily compressed into tablets and other dosage forms. Ethylcelullose can be used on its own or in combination with water-soluble polymers to prepare sustained release film coatings that are frequently used for the coating of micro-particles, pellets and tablets. Ethylcellulose masks the bitter taste of drugs, minimizing the need for added flavoring agents. The PHARM Grades of Aqualon EC are compliant with the requirements of the United States Pharmacopeia / National Formulary and the European Pharmacopeia.

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Aqualon® CMC and Blanose® CMC are anionic water-soluble polymers derived from cellulose reacted with sodium monochloroacetate. CMC is a common thickener, binder, stabilizer, suspending agent, and rheology control agent. Aqualon CMC and Blanose CMC are trademarks typically used in the United States and Europe, respectively. Aqualon CMC grades designated P or PH comply with the monograph requirements for Carboxymethylcellulose Sodium or Carboxymethylcellulose Sodium 12 in the USP/NF current edition. Certain grades may also meet the requirements of the European Pharmacopoeia and the Japanese Pharmacopoeia. BLANOSE CMC PH grades designated as P or PH comply with the monograph requirements of the current edition of the European Pharmacopoeia and the United States Pharmacopoeia / National Formulary. Some grades may also meet the Japanese Pharmacopoeia.

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Klucel® HPC is non-ionic water-soluble cellulose ether, formed by reaction of cellulose with propylene oxide. Klucel provides a remarkable set of physical properties for tablet binding, modified release and film coating. It combines organic solvent or aqueous solubility, thermoplasticity and surface activity with aqueous thickening and stabilizing properties characteristic of other water-soluble cellulose polymers available from Aqualon. Klucel has a longstanding history of safe and effective use in the pharmaceutical industry. The PHARM grades of Klucel HPC comply with the requirements of the National Formulary, the European Pharmacopoeia, the Japanese Pharmacopoeia and the Food Chemicals Codex.

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Cellulose derivatives are often used in tablet formulations as matrices or matrix components to modify the release of drugs. These systems benefit from ease of manufacture, low cost and predictable in vivo performance. Drug release with these systems involve two simultaneous processes–Fickian diffusion and matrix relaxation and erosion. Polymer swelling, concentration and particle size, drug solubility and concentration, pH effects, other excipients and processing variables are important factors when formulating these systems. This summary provides an introduction to some modified release studies with high molecular weight grades of Klucel® hydroxypropylcellulose (HPC HXF*, HXAF*, or HF) and Natrosol® hydroxyethylcellulose (HEC 250 HHX). Incorporation at levels of 15 to 40% is typical. The utility of Aqualon® ethylcellulose (EC) and Aqualon® sodium carboxymethylcellulose (CMC) has also been demonstrated for modified release systems.

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Natrosol® HEC is a non-ionic water-soluble cellulose ether, formed by reaction of cellulose with ethylene oxide. It is used as a modified release tablet matrix, a film former and a thickener, stabilizer and suspending agent for oral and topical applications when a non-ionic material is desired. Natrosol is easily dispersed in cold or hot water to give solutions of varying viscosities and desired properties, yet it is insoluble in organic solvents. The PHARM grades of Natrosol® HEC comply with the requirements of the National Formulary and European Pharmacopoeia. The NF grades of Natrosol HEC comply with the requirements of the National Formulary.

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